Journal article
Bone loss with antiepileptic drug therapy: a twin and sibling study
B Shiek Ahmad, SJ Petty, A Gorelik, TJ O’Brien, KD Hill, JJ Christie, PN Sambrook, JD Wark
Osteoporosis International | SPRINGER LONDON LTD | Published : 2017
Abstract
Summary: Changes in areal bone mineral density (aBMD) and other predictors of bone loss were evaluated in 48 same-sex twin/age-matched sibling pairs discordant for antiepileptic drug (AED) use. AED users had reduced BMD at the hip regions. Prolonged AED users had greater aBMD loss, predicting a higher risk of bone fragility. Introduction: To investigate the longitudinal associations of bone mineral measures with antiepileptic drug (AED) use, including enzyme-inducing (EIAED) and non-enzyme-inducing (NEIAED) types, and other predictors of bone loss in a study of 48 same-sex twin/age-matched sibling pairs (40 female, 8 male) discordant for AED use. Methods: Using dual-energy X-ray absorptiomet..
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Awarded by Royal Melbourne Hospital Neuroscience Foundation
Funding Acknowledgements
The authors would like to express their highest appreciation to all participants for their invaluable contributions and commitments throughout the study, our collaborators, Ms. Mary Sakellarides who continued the work of Dr. Petty on baseline recruitment, the late Ms. Sue Kantor and Ms. Ashwini Kale at Bone and Mineral Medicine, the Royal Melbourne Hospital, for their assistance during the bone scanning of Melbourne-based participants, Professor Richard L Prince and his research team at the Sir Charles Gairdner Hospital for their support for study visits in Western Australia, Ms. Monique Macara from the RNSH who conducted the assessments for Sydney-based participants, the Australian Twin Registry, and all who have been involved with the University of Melbourne Twin and Sibling Research Program.